| 9/2/2018 | UNC Pembroke (2-8) | 20 | at | Winston-Salem State | 23 | D2Ind | ||
| 9/8/2018 | Catawba (4-7) | 34 | at | Winston-Salem State | 7 | SAC | ||
| 9/15/2018 | Winston-Salem State | vs | Elizabeth City State (1-7,0-6) | Rocky Mount NC CCD | ||||
| 9/22/2018 | Virginia Union (8-2,7-1) | 27 | at | Winston-Salem State | 19 | |||
| 9/29/2018 | Winston-Salem State | 17 | at | Bowie State (10-3,7-1) | 20 | |||
| 10/6/2018 | Winston-Salem State | 34 | at | Johnson C Smith (2-8,2-6) | 14 | |||
| 10/13/2018 | St Augustine's (2-7,2-5) | 6 | at | Winston-Salem State | 36 | |||
| 10/20/2018 | Livingstone (3-6,2-5) | 19 | at | Winston-Salem State | 34 | |||
| 10/27/2018 | Winston-Salem State | 21 | at | Shaw (5-5,4-3) | 26 | |||
| 11/3/2018 | Winston-Salem State | 51 | at | Fayetteville State (6-3,6-2) | 21 |
| vs Winston-Salem State | vs Other Opponents | Winston-Salem State compared to OOs | |
| Record: | 4-5 | 39-51 | |
| Points Scored: | 20.78 | 25.59 | 4.81 |
| Points Allowed: | 26.89 | 29.59 | -2.70 |
| Margin: | -6.11 | -4.00 | 2.11 |
| Total Points: | 47.67 | 55.18 | -7.51 |