| Game | Pred: | Vscr | Hscr | Actual: | Vscr | Hscr | Delta: | Vscr | Hscr | Margin: | Pred | Act | Δ |
| Oklahoma (12-2) (+11.4) vs Alabama (14-0) Sooners 29 Crimson Tide 41 | 29.5 | 40.9 | 34 | 45 | 4.5 | 4.1 | 11 | 11 | 0 | ||||
| Notre Dame (12-1) (+10.2) vs Clemson (14-0) Fighting Irish 20 Tigers 30 | 20.3 | 30.5 | 3 | 30 | 17.3 | 0.5 | 10 | 27 | -17 | ||||
| Michigan (10-3) (-1.5) vs Florida (10-3) Wolverines 27 Gators 26 | 27.4 | 26.0 | 15 | 41 | 12.4 | 15.0 | Miss | 1 | -26 | 27 | |||
| Arkansas State (8-5) (+0.4) vs Nevada (8-5) Red Wolves 28 Wolf Pack 29 | 28.2 | 28.6 | 13 | 16 | 15.2 | 12.6 | 0 | 3 | -3 | ||||
| South Carolina (7-6) (+0.7) vs Virginia (8-5) Gamecocks 26 Cavaliers 27 | 26.0 | 26.7 | 0 | 28 | 26.0 | 1.3 | 1 | 28 | -27 | ||||
| Missouri (8-5) (-4.8) vs Oklahoma State (7-6) (Monday) Tigers 36 Cowboys 31 | 35.6 | 30.7 | 33 | 38 | 2.6 | 7.3 | Miss | 5 | -5 | 10 | |||
| Michigan State (7-6) (+3.0) vs Oregon (9-4) (Monday) Spartans 22 Ducks 25 | 22.4 | 25.4 | 6 | 7 | 16.4 | 18.4 | 3 | 1 | 2 | ||||
| Stanford (9-4) (-5.6) vs Pittsburgh (7-7) (Monday) Cardinal 29 Panthers 23 | 29.1 | 23.4 | 14 | 13 | 15.1 | 10.4 | 6 | 1 | 5 | ||||
| North Carolina State (9-4) (+4.1) vs Texas A&M (9-4) (Monday) Wolfpack 28 Aggies 32 | 27.7 | 31.9 | 13 | 52 | 14.7 | 20.1 | 4 | 39 | -35 | ||||
| Northwestern (9-5) (+4.0) vs Utah (9-5) (Monday) Wildcats 22 Utes 26 | 21.6 | 25.7 | 31 | 20 | 9.4 | 5.7 | Miss | 4 | -11 | 15 | |||
| Cincinnati (11-2) (-10.4) vs Virginia Tech (6-7) (Monday) Bearcats 33 Hokies 23 | 33.3 | 22.9 | 35 | 31 | 1.7 | 8.1 | 10 | 4 | 6 | ||||
| LSU (10-3) (+0.4) vs UCF (12-1) (Tuesday) Tigers 29 Knights 29 | 29.0 | 29.4 | 40 | 32 | 11.0 | 2.6 | Miss | 0 | -8 | 8 | |||
| Texas (10-4) (+8.3) vs Georgia (11-3) (Tuesday) Longhorns 24 Bulldogs 32 | 24.0 | 32.3 | 28 | 21 | 4.0 | 11.3 | Miss | 8 | -7 | 15 | |||
| Mississippi State (8-5) (-1.1) vs Iowa (9-4) (Tuesday) Bulldogs 23 Hawkeyes 22 | 22.7 | 21.6 | 22 | 27 | 0.7 | 5.4 | Miss | 1 | -5 | 6 | |||
| Washington (10-4) (+2.9) vs Ohio State (13-1) (Tuesday) Huskies 26 Buckeyes 29 | 25.6 | 28.5 | 23 | 28 | 2.6 | 0.5 | 3 | 5 | -2 | ||||
| Kentucky (10-3) (+0.3) vs Penn State (9-4) (Tuesday) Wildcats 24 Nittany Lions 25 | 24.3 | 24.6 | 37 | 24 | 12.7 | 0.6 | Miss | 0 | -13 | 13 | |||
| Eastern Washington (12-2) (+9.1) vs North Dakota State (14-0) Eagles 24 Bison 33 | 23.8 | 32.9 | |||||||||||
| Clemson (14-0) (-0.5) vs Alabama (14-0) (Monday) Tigers 28 Crimson Tide 27 | 28.0 | 27.5 |
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