| 8/31/2017 | Quincy (3-8) | 6 | at | Midwestern State | 53 | GLV | ||
| 9/9/2017 | Midwestern State | at | West Florida (11-4) | Cancelled WX | at GSC | |||
| 9/16/2017 | Texas A&M-Kingsville (4-7,2-6) | 13 | at | Midwestern State | 35 | |||
| 9/30/2017 | Western New Mexico (4-7,3-5) | 24 | at | Midwestern State | 35 | |||
| 10/7/2017 | Texas A&M-Commerce (14-1,7-1) | 42 | at | Midwestern State | 47 | |||
| 10/14/2017 | Midwestern State | 41 | at | Angelo State (6-5,4-4) | 27 | |||
| 10/21/2017 | West Texas A&M (3-8,1-7) | 3 | at | Midwestern State | 45 | |||
| 10/28/2017 | Midwestern State | 66 | vs | Texas-Permian Basin (2-9,1-7) | 8 | Midland TX | ||
| 11/4/2017 | Tarleton State (6-6,4-4) | 42 | at | Midwestern State | 45 | OT | ||
| 11/11/2017 | Midwestern State | 56 | at | Eastern New Mexico (8-2,6-2) | 43 | |||
| 11/18/2017 | Sioux Falls (9-3) | 20 | at | Midwestern State | 24 | NSIC | ||
| 11/25/2017 | Midwestern State | 21 | at | Minnesota State-Mankato (13-1) | 63 | D2 Playoff Round 2 | at NSIC |
| vs Midwestern State | vs Other Opponents | Midwestern State compared to OOs | |
| Record: | 1-10 | 82-51 | |
| Points Scored: | 26.45 | 28.09 | 1.64 |
| Points Allowed: | 42.55 | 24.58 | 17.97 |
| Margin: | -16.10 | 3.51 | 19.61 |
| Total Points: | 69.00 | 52.67 | 16.33 |