| 9/9/2017 | Mississippi Valley State (2-9) | 3 | at | Southern Illinois | 55 | SWAC | ||
| 9/16/2017 | Southern Illinois | 35 | at | SE Missouri State (3-8) | 17 | at OVC | ||
| 9/23/2017 | Southern Illinois | 31 | at | Memphis (10-3) | 44 | at AAC | ||
| 9/30/2017 | Northern Iowa (8-5,6-3) | 24 | at | Southern Illinois | 17 | |||
| 10/7/2017 | Southern Illinois | 14 | at | South Dakota State (11-3,7-2) | 49 | |||
| 10/14/2017 | Illinois State (6-5,4-4) | 7 | at | Southern Illinois | 42 | |||
| 10/21/2017 | Southern Illinois | 45 | at | Indiana State (0-11,0-8) | 24 | |||
| 10/28/2017 | Southern Illinois | 0 | at | South Dakota (8-5,4-4) | 42 | |||
| 11/4/2017 | Missouri State (3-8,2-6) | 36 | at | Southern Illinois | 28 | |||
| 11/11/2017 | Youngstown State (6-5,4-4) | 28 | at | Southern Illinois | 20 | |||
| 11/18/2017 | Southern Illinois | 14 | at | Western Illinois (8-4,5-3) | 28 |
| vs Southern Illinois | vs Other Opponents | Southern Illinois compared to OOs | |
| Record: | 7-4 | 58-62 | |
| Points Scored: | 27.45 | 29.38 | 1.93 |
| Points Allowed: | 27.36 | 28.30 | -0.94 |
| Margin: | 0.09 | 1.08 | 0.99 |
| Total Points: | 54.81 | 57.68 | -2.87 |