| 8/31/2017 | Duquesne (7-4) | 13 | at | South Dakota State | 51 | NE | ||
| 9/9/2017 | South Dakota State | 31 | at | Montana State (5-6) | 27 | at BSky | ||
| 9/16/2017 | Drake (7-4) | 10 | at | South Dakota State | 51 | Pio | ||
| 9/30/2017 | South Dakota State | 7 | at | Youngstown State (6-5,4-4) | 19 | |||
| 10/7/2017 | Southern Illinois (4-7,2-6) | 14 | at | South Dakota State | 49 | |||
| 10/14/2017 | Northern Iowa (8-5,6-3) | 38 | at | South Dakota State | 18 | |||
| 10/21/2017 | South Dakota State | 62 | at | Missouri State (3-8,2-6) | 30 | |||
| 10/28/2017 | South Dakota State | 52 | at | Western Illinois (8-4,5-3) | 24 | |||
| 11/4/2017 | North Dakota State (14-1,7-1) | 21 | at | South Dakota State | 33 | |||
| 11/11/2017 | Illinois State (6-5,4-4) | 24 | at | South Dakota State | 27 | OT | ||
| 11/18/2017 | South Dakota State | 31 | at | South Dakota (8-5,4-4) | 28 | |||
| 12/2/2017 | Northern Iowa (8-5,6-3) | 22 | at | South Dakota State | 37 | 1AA Playoff Round 2 | ||
| 12/9/2017 | New Hampshire (9-5) | 14 | at | South Dakota State | 56 | 1AA Playoff Quarterfinal | CAAF | |
| 12/16/2017 | South Dakota State | 16 | vs | James Madison (14-1) | 51 | 1AA Semifinal | vs CAAF |
| vs South Dakota State | vs Other Opponents | South Dakota State compared to OOs | |
| Record: | 3-11 | 103-53 | |
| Points Scored: | 23.93 | 31.08 | 7.15 |
| Points Allowed: | 37.21 | 21.20 | 16.01 |
| Margin: | -13.28 | 9.88 | 23.16 |
| Total Points: | 61.14 | 52.28 | 8.86 |