| 9/3/2017 | South Carolina State (3-7) | 8 | at | Southern | 14 | MEAC | ||
| 9/9/2017 | Southern | 0 | at | Southern Miss (8-5) | 45 | at CUSA | ||
| 9/16/2017 | Southern | 17 | at | Texas-San Antonio (6-5) | 51 | at CUSA | ||
| 9/23/2017 | Southern | 31 | at | Alcorn State (7-5,6-3) | 48 | |||
| 9/30/2017 | Fort Valley State (5-5) | 14 | at | Southern | 31 | SIAC (D2) | ||
| 10/7/2017 | Alabama A&M (4-7,3-4) | 14 | at | Southern | 35 | |||
| 10/21/2017 | Southern | 35 | at | Jackson State (3-8,3-5) | 17 | |||
| 10/28/2017 | Southern | 47 | vs | Ark Pine Bluff (2-9,1-6) | 40 | Little Rock AR | ||
| 11/4/2017 | Prairie View (6-5,4-3) | 31 | at | Southern | 37 | |||
| 11/11/2017 | Southern | 33 | at | Texas Southern (2-9,2-6) | 7 | |||
| 11/25/2017 | Southern | 21 | vs | Grambling (11-2,9-0) | 30 | New Orleans LA |
| vs Southern | vs Other Opponents | Southern compared to OOs | |
| Record: | 4-7 | 53-60 | |
| Points Scored: | 27.73 | 23.23 | -4.50 |
| Points Allowed: | 27.36 | 23.93 | 3.43 |
| Margin: | 0.37 | -0.70 | -1.07 |
| Total Points: | 55.09 | 47.16 | 7.93 |