| 9/3/2017 | South Carolina State | 8 | at | Southern (7-4) | 14 | at SWAC | ||
| 9/9/2017 | Charleston Southern (6-5) | at | South Carolina State | Postponed WX | BigS | |||
| 9/16/2017 | Johnson C Smith (2-8) | 0 | at | South Carolina State | 41 | CIAA (D2) | ||
| 9/21/2017 | South Carolina State | 28 | at | North Carolina Central (7-4,5-3) | 33 | |||
| 9/30/2017 | North Carolina A&T (12-0,8-0) | 21 | at | South Carolina State | 7 | |||
| 10/6/2017 | Morgan State (1-10,1-7) | 14 | at | South Carolina State | 35 | |||
| 10/14/2017 | South Carolina State | 9 | at | Bethune-Cookman (7-4,6-2) | 12 | |||
| 10/21/2017 | South Carolina State | 14 | at | Delaware State (2-9,2-6) | 17 | |||
| 10/28/2017 | Howard (7-4,6-2) | 28 | at | South Carolina State | 20 | |||
| 11/11/2017 | Hampton (6-5,5-3) | 15 | at | South Carolina State | 33 | |||
| 11/18/2017 | South Carolina State | 10 | at | Savannah State (3-8,3-5) | 34 |
| vs South Carolina State | vs Other Opponents | South Carolina State compared to OOs | |
| Record: | 7-3 | 53-58 | |
| Points Scored: | 18.80 | 22.75 | 3.95 |
| Points Allowed: | 20.50 | 26.44 | -5.94 |
| Margin: | -1.70 | -3.69 | -1.99 |
| Total Points: | 39.30 | 49.19 | -9.89 |