| 9/2/2017 | Prairie View | at | Texas Southern (2-9,2-6) | Postponed | ||||
| 9/7/2017 | Sam Houston (12-2) | 44 | at | Prairie View | 31 | SLC | ||
| 9/16/2017 | Prairie View | 13 | at | Nicholls State (8-4) | 44 | at SLC | ||
| 9/23/2017 | Prairie View | 34 | at | Alabama State (5-6,4-3) | 0 | |||
| 9/30/2017 | Jackson State (3-8,3-5) | 9 | at | Prairie View | 38 | |||
| 10/7/2017 | Grambling (11-2,9-0) | 34 | vs | Prairie View | 21 | Dallas TX | ||
| 10/14/2017 | Prairie View | 21 | at | Alcorn State (7-5,6-3) | 34 | |||
| 10/28/2017 | Bacone (2-9) | 17 | at | Prairie View | 34 | CSFL (NAIA) | ||
| 11/4/2017 | Prairie View | 31 | at | Southern (7-4,5-2) | 37 | |||
| 11/11/2017 | Ark Pine Bluff (2-9,1-6) | 12 | at | Prairie View | 35 | |||
| 11/16/2017 | Prairie View | 42 | at | Incarnate Word (1-10) | 28 | at SLC | ||
| 11/25/2017 | Prairie View | 30 | at | Texas Southern (2-9,2-6) | 16 |
| vs Prairie View | vs Other Opponents | Prairie View compared to OOs | |
| Record: | 5-6 | 57-70 | |
| Points Scored: | 25.00 | 23.94 | -1.06 |
| Points Allowed: | 30.00 | 28.46 | 1.54 |
| Margin: | -5.00 | -4.52 | 0.48 |
| Total Points: | 55.00 | 52.40 | 2.60 |