| 9/3/2016 | Muskingum (4-6) | 17 | at | Waynesburg | 16 | OAC | ||
| 9/10/2016 | Waynesburg | 7 | at | Westminster PA (8-3,6-3) | 28 | |||
| 9/17/2016 | Waynesburg | 23 | at | Carnegie Mellon (7-4,6-2) | 35 | |||
| 9/24/2016 | Case Western Reserve (9-1,7-1) | 35 | at | Waynesburg | 7 | |||
| 10/1/2016 | Waynesburg | 14 | at | Grove City (0-10,0-9) | 10 | |||
| 10/8/2016 | Geneva (3-7,3-6) | 9 | at | Waynesburg | 10 | |||
| 10/15/2016 | Thomas More (9-2,8-0) | 40 | at | Waynesburg | 7 | |||
| 10/29/2016 | Waynesburg | 42 | at | Thiel (4-6,3-6) | 50 | |||
| 11/5/2016 | Waynesburg | 12 | at | St Vincent (5-5,4-5) | 30 | |||
| 11/12/2016 | Washington & Jefferson (9-2,7-2) | 14 | at | Waynesburg | 10 |
| vs Waynesburg | vs Other Opponents | Waynesburg compared to OOs | |
| Record: | 8-2 | 50-44 | |
| Points Scored: | 26.80 | 30.63 | 3.83 |
| Points Allowed: | 14.80 | 28.70 | -13.90 |
| Margin: | 12.00 | 1.93 | -10.07 |
| Total Points: | 41.60 | 59.33 | -17.73 |