| 9/3/2016 | Washington U | 41 | at | Carnegie Mellon (7-4) | 34 | OT | at TPAC | |
| 9/17/2016 | Centre (8-2,6-2) | 39 | at | Washington U | 28 | |||
| 9/24/2016 | Washington U | 36 | at | Birmingham-Southern (1-9,1-7) | 21 | |||
| 10/1/2016 | Berry (9-1,7-1) | 10 | at | Washington U | 34 | |||
| 10/8/2016 | Washington U | 56 | at | Rhodes (6-4,4-4) | 35 | |||
| 10/15/2016 | Sewanee (0-10,0-8) | 6 | at | Washington U | 34 | |||
| 10/22/2016 | Washington U | 31 | at | Millsaps (3-7,2-6) | 28 | |||
| 10/29/2016 | Case Western Reserve (9-1) | 56 | at | Washington U | 38 | TPAC | ||
| 11/5/2016 | Hendrix (7-3,5-3) | 46 | at | Washington U | 49 | |||
| 11/12/2016 | Washington U | 43 | at | Chicago (4-6,4-4) | 34 | |||
| 11/19/2016 | Washington U | 13 | at | Wisconsin-Oshkosh (12-2) | 49 | at WIAC |
| vs Washington U | vs Other Opponents | Washington U compared to OOs | |
| Record: | 3-8 | 63-41 | |
| Points Scored: | 32.55 | 32.30 | -0.25 |
| Points Allowed: | 36.64 | 26.89 | 9.75 |
| Margin: | -4.09 | 5.41 | 9.50 |
| Total Points: | 69.19 | 59.19 | 10.00 |