| 9/3/2016 | Hanover (4-6) | 13 | at | Centre | 35 | HCA | ||
| 9/10/2016 | Centre | 56 | at | Anderson (1-9) | 14 | at HCA | ||
| 9/17/2016 | Centre | 39 | at | Washington U (8-3,7-1) | 28 | |||
| 9/24/2016 | Chicago (4-6,4-4) | 27 | at | Centre | 49 | |||
| 10/1/2016 | Centre | 28 | at | Hendrix (7-3,5-3) | 35 | |||
| 10/8/2016 | Millsaps (3-7,2-6) | 21 | at | Centre | 40 | |||
| 10/22/2016 | Sewanee (0-10,0-8) | 10 | at | Centre | 49 | |||
| 10/29/2016 | Centre | 45 | at | Birmingham-Southern (1-9,1-7) | 30 | |||
| 11/5/2016 | Centre | 66 | at | Rhodes (6-4,4-4) | 28 | |||
| 11/12/2016 | Berry (9-1,7-1) | 21 | at | Centre | 19 |
| vs Centre | vs Other Opponents | Centre compared to OOs | |
| Record: | 2-8 | 41-50 | |
| Points Scored: | 22.70 | 29.23 | 6.53 |
| Points Allowed: | 42.60 | 31.96 | 10.64 |
| Margin: | -19.90 | -2.73 | 17.17 |
| Total Points: | 65.30 | 61.19 | 4.11 |