| 9/2/2016 | North Carolina Wesleyan | 28 | at | Stevenson (9-2) | 42 | at MidAC | ||
| 9/10/2016 | Mount Union (12-2) | 45 | at | North Carolina Wesleyan | 10 | OAC | ||
| 9/17/2016 | North Carolina Wesleyan | 31 | at | Shenandoah (6-4) | 13 | at ODC | ||
| 10/1/2016 | Huntingdon AL (9-2,6-1) | 31 | at | North Carolina Wesleyan | 41 | |||
| 10/8/2016 | North Carolina Wesleyan | 17 | at | Maryville (8-2,6-1) | 31 | |||
| 10/15/2016 | Methodist (3-6,2-4) | vs | North Carolina Wesleyan | Cancelled WX | ||||
| 10/22/2016 | North Carolina Wesleyan | 44 | at | Greensboro (1-9,0-7) | 0 | |||
| 10/29/2016 | Averett (5-5,4-3) | 38 | at | North Carolina Wesleyan | 34 | |||
| 11/5/2016 | LaGrange (3-7,1-6) | 23 | at | North Carolina Wesleyan | 49 | |||
| 11/12/2016 | North Carolina Wesleyan | 27 | at | Ferrum (6-4,4-3) | 13 |
| vs North Carolina Wesleyan | vs Other Opponents | North Carolina Wesleyan compared to OOs | |
| Record: | 4-5 | 58-38 | |
| Points Scored: | 26.22 | 34.22 | 8.00 |
| Points Allowed: | 31.22 | 27.59 | 3.63 |
| Margin: | -5.00 | 6.63 | 11.63 |
| Total Points: | 57.44 | 61.81 | -4.37 |