| 9/2/2016 | North Carolina Wesleyan | 28 | at | Stevenson | 42 | @ MidAC | ||
| 9/3/2016 | Hampden-Sydney | 28 | at | Averett | 38 | ODC | ||
| Maryville | 33 | at | Berry | 34 | @ SAA | |||
| LaGrange | 47 | at | Birmingham-Southern | 27 | @ SAA | |||
| Emory & Henry | 38 | at | Ferrum | 39 | ODC | |||
| Greensboro | 0 | at | Guilford | 69 | @ ODC | |||
| Huntingdon AL | 52 | at | Louisiana College | 49 | @ ASWC | |||
| Apprentice | 20 | at | Methodist | 24 | D3Ind | |||
| 9/10/2016 | Apprentice | 42 | at | Greensboro | 22 | D3Ind | ||
| Methodist | 32 | at | Guilford | 47 | @ ODC | |||
| Maryville | 38 | at | Hanover | 0 | @ HCA | |||
| Birmingham-Southern | 28 | at | Huntingdon AL | 49 | SAA | |||
| Berry | 52 | at | LaGrange | 37 | SAA | |||
| Mount Union | 45 | at | North Carolina Wesleyan | 10 | OAC | |||
| Averett | 10 | at | Randolph-Macon | 44 | @ ODC | |||
| Ferrum | 33 | at | Shenandoah | 53 | @ ODC | |||
| 9/17/2016 | LaGrange | 54 | at | Ave Maria | 17 | @ Sun (NAIA) | ||
| Guilford | 30 | at | Averett | 28 | ODC | |||
| Hampden-Sydney | 20 | vs | Ferrum | 42 | Salem VA | vs ODC | ||
| Gallaudet | 6 | at | Greensboro | 21 | ECFC | |||
| Belhaven | 21 | at | Huntingdon AL | 65 | ASWC | |||
| Emory & Henry | 36 | at | Maryville | 43 | ODC | |||
| Methodist | 16 | at | Randolph-Macon | 34 | @ ODC | |||
| North Carolina Wesleyan | 31 | at | Shenandoah | 13 | @ ODC | |||
| 10/1/2016 | Ferrum | 30 | at | Greensboro | 0 | |||
| Averett | 65 | at | LaGrange | 62 | 4OT | |||
| Maryville | 52 | at | Methodist | 13 | ||||
| Huntingdon AL | 31 | at | North Carolina Wesleyan | 41 | ||||
| 10/6/2016 | LaGrange | 35 | at | Greensboro | 26 | |||
| 10/8/2016 | Ferrum | 27 | at | Huntingdon AL | 48 | |||
| North Carolina Wesleyan | 17 | at | Maryville | 31 | ||||
| 10/9/2016 | Methodist | at | Averett | PPD | ||||
| 10/15/2016 | Greensboro | 6 | at | Averett | 52 | |||
| Maryville | 42 | at | Ferrum | 19 | ||||
| LaGrange | 13 | at | Huntingdon AL | 55 | ||||
| Methodist | vs | North Carolina Wesleyan | Cancelled WX | |||||
| 10/22/2016 | North Carolina Wesleyan | 44 | at | Greensboro | 0 | |||
| Ferrum | 44 | at | LaGrange | 20 | ||||
| Averett | 26 | at | Maryville | 31 | ||||
| Huntingdon AL | 47 | at | Methodist | 14 | ||||
| 10/29/2016 | Methodist | 30 | at | Ferrum | 35 | |||
| Greensboro | 0 | at | Huntingdon AL | 71 | ||||
| Maryville | 30 | at | LaGrange | 19 | ||||
| Averett | 38 | at | North Carolina Wesleyan | 34 | ||||
| 11/5/2016 | Ferrum | 14 | at | Averett | 3 | |||
| Huntingdon AL | 28 | at | Maryville | 24 | ||||
| Greensboro | 6 | at | Methodist | 38 | ||||
| LaGrange | 23 | at | North Carolina Wesleyan | 49 | ||||
| 11/12/2016 | Huntingdon AL | 42 | at | Averett | 14 | |||
| North Carolina Wesleyan | 27 | at | Ferrum | 13 | ||||
| Maryville | 70 | at | Greensboro | 14 | ||||
| Methodist | 43 | at | LaGrange | 26 | ||||
| 11/19/2016 | Averett | 28 | at | Methodist | 14 | |||
| Huntingdon AL | 10 | at | Wheaton | 45 | @ CCIW |