| 9/1/2016 | Central Missouri (9-3,9-2) | 34 | at | Pittsburg State | 27 | | | |
| 9/8/2016 | Pittsburg State | 45 | at | Central Oklahoma (3-8,3-8) | 31 | | | |
| 9/17/2016 | Northeastern State (2-9,2-9) | 37 | at | Pittsburg State | 38 | OT | | |
| 9/24/2016 | Pittsburg State | 50 | at | Lindenwood (3-8,3-8) | 19 | | | |
| 10/1/2016 | Pittsburg State | 45 | at | Washburn (7-5,7-4) | 27 | | | |
| 10/8/2016 | Fort Hays State (8-4,7-4) | 54 | at | Pittsburg State | 41 | | | |
| 10/15/2016 | Pittsburg State | 55 | at | Missouri Western (4-7,4-7) | 47 | | | |
| 10/22/2016 | Emporia State (11-2,10-2) | 41 | at | Pittsburg State | 36 | | | |
| 10/29/2016 | Pittsburg State | 10 | at | Northwest Missouri State (15-0,12-0) | 69 | | | |
| 11/5/2016 | Nebraska-Kearney (1-10,1-10) | 21 | at | Pittsburg State | 52 | | | |
| 11/12/2016 | Pittsburg State | 45 | at | Missouri Southern (2-9,2-9) | 31 | | | |