| 9/3/2016 | Huntingdon AL (9-2) | 52 | at | Louisiana College | 49 | USASC | ||
| 9/10/2016 | Louisiana College | 49 | at | Texas College (0-9) | 18 | at CSFL | ||
| 9/17/2016 | Texas Lutheran (2-8) | 28 | at | Louisiana College | 58 | SCAC | ||
| 10/1/2016 | Howard Payne (0-10,0-7) | 7 | at | Louisiana College | 35 | |||
| 10/8/2016 | Hardin-Simmons (9-2,6-1) | 42 | at | Louisiana College | 21 | |||
| 10/15/2016 | Louisiana College | 14 | at | Sul Ross State (6-4,5-2) | 21 | |||
| 10/22/2016 | Belhaven (2-8,1-6) | 30 | at | Louisiana College | 52 | |||
| 10/29/2016 | East Texas Baptist (7-3,4-3) | 64 | at | Louisiana College | 62 | |||
| 11/5/2016 | Louisiana College | 28 | at | McMurry (4-5,3-4) | 34 | |||
| 11/12/2016 | Louisiana College | 7 | at | Mary Hardin-Baylor (15-0,7-0) | 63 |
| vs Louisiana College | vs Other Opponents | Louisiana College compared to OOs | |
| Record: | 6-4 | 48-47 | |
| Points Scored: | 35.90 | 34.81 | -1.09 |
| Points Allowed: | 37.50 | 32.92 | 4.58 |
| Margin: | -1.60 | 1.89 | 3.49 |
| Total Points: | 73.40 | 67.73 | 5.67 |