| 9/3/2016 | Greensboro (1-9) | 0 | at | Guilford | 69 | USASC | ||
| 9/10/2016 | Methodist (3-6) | 32 | at | Guilford | 47 | USASC | ||
| 9/17/2016 | Guilford | 30 | at | Averett (5-5) | 28 | at USASC | ||
| 10/1/2016 | Catholic (3-7,0-7) | 0 | at | Guilford | 59 | |||
| 10/8/2016 | Guilford | 15 | at | Hampden-Sydney (3-7,3-4) | 21 | |||
| 10/15/2016 | Washington and Lee (6-4,5-2) | 48 | at | Guilford | 34 | |||
| 10/22/2016 | Guilford | 28 | at | Shenandoah (6-4,4-3) | 33 | |||
| 10/29/2016 | Bridgewater VA (5-5,4-3) | 42 | at | Guilford | 41 | |||
| 11/5/2016 | Guilford | 10 | at | Randolph-Macon (9-2,6-1) | 31 | |||
| 11/12/2016 | Guilford | 7 | at | Emory & Henry (6-4,5-2) | 34 |
| vs Guilford | vs Other Opponents | Guilford compared to OOs | |
| Record: | 6-4 | 41-49 | |
| Points Scored: | 26.90 | 27.40 | 0.50 |
| Points Allowed: | 34.00 | 30.48 | 3.52 |
| Margin: | -7.10 | -3.08 | 4.02 |
| Total Points: | 60.90 | 57.88 | 3.02 |