| 8/25/2016 | Wayland Baptist | 37 | at | Lyon | 14 | |||
| 9/3/2016 | Southwestern Assemblies of God | 27 | at | Howard Payne | 21 | @ ASWC (D3) | ||
| Texas College | 6 | at | Lane | 44 | @ SIAC (D2) | |||
| Langston | 23 | at | Lincoln MO | 13 | @ GLV (D2) | |||
| Lyon | 17 | at | Lindsey Wilson | 63 | @ MSC | |||
| Bacone | 14 | at | Missouri S&T | 62 | @ GLV (D2) | |||
| 9/10/2016 | Robert Morris IL | 48 | at | Bacone | 6 | MSFA | ||
| Southwestern Assemblies of God | 23 | at | East Texas Baptist | 85 | @ ASWC (D3) | |||
| Bethany KS | 7 | vs | Langston | 30 | Oklahoma City OK | vs KCAC | ||
| Hendrix | 49 | at | Lyon | 14 | SAA (D3) | |||
| Louisiana College | 49 | at | Texas College | 18 | ASWC (D3) | |||
| Arizona Christian | 34 | at | Texas-Permian Basin | 49 | @ LSC (D2) | |||
| Sul Ross State | 48 | at | Wayland Baptist | 27 | ASWC (D3) | |||
| 9/17/2016 | Lane | 46 | at | Langston | 44 | SIAC (D2) | ||
| Texas College | 6 | at | McMurry | 63 | @ ASWC (D3) | |||
| Arizona Christian | 30 | at | Sul Ross State | 27 | OT | @ ASWC (D3) | ||
| Hardin-Simmons | 61 | at | Southwestern Assemblies of God | 24 | ASWC (D3) | |||
| Bacone | 6 | at | Tennessee-Martin | 84 | @ OVC (1AA) | |||
| Howard Payne | 37 | at | Wayland Baptist | 40 | ASWC (D3) | |||
| 9/24/2016 | Lyon | 21 | at | Bacone | 34 | |||
| Arizona Christian | 7 | at | Davenport | 20 | @ NAIAInd | |||
| Austin | 17 | at | Southwestern Assemblies of God | 23 | SCAC (D3) | |||
| Webber International | 20 | at | Wayland Baptist | 31 | Sun | |||
| 10/1/2016 | Langston | 10 | at | Arizona Christian | 34 | |||
| Southwestern Assemblies of God | 42 | at | Lyon | 48 | OT | |||
| Bacone | 35 | at | Texas College | 26 | ||||
| 10/8/2016 | Wayland Baptist | 26 | at | Bacone | 20 | |||
| Texas College | 21 | at | Lyon | 35 | ||||
| Arizona Christian | 29 | at | Southwestern Assemblies of God | 22 | ||||
| 10/15/2016 | Texas College | 7 | at | Arizona Christian | 57 | |||
| Bacone | 32 | at | Langston | 33 | ||||
| Southwestern Assemblies of God | 14 | at | Wayland Baptist | 24 | ||||
| 10/22/2016 | Bacone | 0 | at | Eastern New Mexico | 62 | @ LSC (D2) | ||
| Arizona Christian | 34 | at | Lyon | 17 | ||||
| Langston | 63 | at | Southwestern Assemblies of God | 10 | ||||
| Wayland Baptist | 41 | at | Texas College | 14 | ||||
| 10/29/2016 | Warner U. | 38 | at | Arizona Christian | 28 | Sun | ||
| Southwestern Assemblies of God | 51 | at | Bacone | 26 | ||||
| Langston | 70 | at | Texas College | 13 | ||||
| Lyon | 14 | at | Wayland Baptist | 52 | ||||
| 11/5/2016 | Wayland Baptist | 35 | at | Arizona Christian | 45 | |||
| Lyon | 12 | at | Langston | 40 | ||||
| Texas College | 39 | at | Southwestern Assemblies of God | 57 | ||||
| 11/12/2016 | Bacone | 12 | at | Arizona Christian | 47 | |||
| Lyon | 38 | at | Missouri Baptist | 70 | @ MSFA | |||
| Langston | 54 | at | Wayland Baptist | 10 |