| 9/4/2015 | Michigan State | 37 | at | Western Michigan (8-5) | 24 | at MAC | ||
| 9/12/2015 | Oregon (9-4) | 28 | at | Michigan State | 31 | P12 | ||
| 9/19/2015 | Air Force (8-6) | 21 | at | Michigan State | 35 | MW | ||
| 9/26/2015 | Central Michigan (7-6) | 10 | at | Michigan State | 30 | MAC | ||
| 10/3/2015 | Purdue (2-10,1-7) | 21 | at | Michigan State | 24 | |||
| 10/10/2015 | Michigan State | 31 | at | Rutgers (4-8,1-7) | 24 | |||
| 10/17/2015 | Michigan State | 27 | at | Michigan (10-3,6-2) | 23 | |||
| 10/24/2015 | Indiana (6-7,2-6) | 26 | at | Michigan State | 52 | |||
| 11/7/2015 | Michigan State | 38 | at | Nebraska (6-7,3-5) | 39 | |||
| 11/14/2015 | Maryland (3-9,1-7) | 7 | at | Michigan State | 24 | |||
| 11/21/2015 | Michigan State | 17 | at | Ohio State (12-1,7-1) | 14 | |||
| 11/28/2015 | Penn State (7-6,4-4) | 16 | at | Michigan State | 55 | |||
| 12/5/2015 | Michigan State | 16 | vs | Iowa (12-2,8-1) | 13 | B10 Championship (Indianapolis IN) | ||
| 12/31/2015 | Michigan State | 0 | vs | Alabama (14-1) | 38 | Cotton Bowl (Arlington TX) | vs SEC |
| vs Michigan State | vs Other Opponents | Michigan State compared to OOs | |
| Record: | 2-12 | 106-63 | |
| Points Scored: | 21.71 | 32.47 | 10.76 |
| Points Allowed: | 29.79 | 26.08 | 3.71 |
| Margin: | -8.08 | 6.39 | 14.47 |
| Total Points: | 51.50 | 58.55 | -7.05 |