| 9/4/2010 | Widener Pride 0 @ Alfred 37 | |
| 9/18/2010 | Alfred 24 @ St Lawrence Saints 16 | |
| 9/25/2010 | Alfred 35 @ Springfield Pride 28 | † |
| 10/2/2010 | Frostburg State Bobcats 24 @ Alfred 49 | |
| 10/9/2010 | Alfred 35 @ Hartwick Hawks 14 | † |
| 10/16/2010 | Alfred 24 @ Rensselaer Engineers 27 | |
| 10/23/2010 | St John Fisher Cardinals 31 @ Alfred 42 | † |
| 10/30/2010 | Rochester Yellow Jackets 24 @ Alfred 14 | |
| 11/6/2010 | Ithaca Bombers 17 @ Alfred 31 | † |
| 11/13/2010 | Alfred 37 @ Utica Pioneers 20 | † |
| 11/20/2010 | SUNY-Maritime Privateers 0 @ Alfred 60 (D3 Playoffs Round 1) | |
| 11/27/2010 | Alfred 34 @ Cortland Red Dragons 20 | |
| 12/4/2010 | Alfred 7 @ Mount Union Purple Raiders 37 |