| 9/4/2010 | Geneva Golden Tornadoes 32 @ Frostburg State 27 | |
| 9/11/2010 | Wesley Wolverines 47 @ Frostburg State 0 | † |
| 9/18/2010 | Christopher Newport Captains 31 @ Frostburg State 33 | |
| 9/25/2010 | Frostburg State 14 @ Randolph-Macon Yellow Jackets 48 | |
| 10/2/2010 | Frostburg State 24 @ Alfred Saxons 49 | |
| 10/16/2010 | Frostburg State 6 @ Washington & Jefferson Presidents 21 | |
| 10/23/2010 | Frostburg State 7 @ Waynesburg Yellow Jackets 41 | |
| 10/30/2010 | Frostburg State 6 @ St John Fisher Cardinals 38 | |
| 11/6/2010 | Apprentice Ship Builders 21 @ Frostburg State 25 | † |
| 11/13/2010 | Salisbury Seagulls 37 @ Frostburg State 6 | † |