| 9/4/2010 | St Lawrence Saints 3 @ Ithaca 33 | |
| 9/11/2010 | Union NY Dutchmen 20 @ Ithaca 28 | |
| 9/18/2010 | Ithaca 31 @ Widener Pride 7 | |
| 9/25/2010 | Ithaca 24 @ Lycoming Warriors 26 | |
| 10/2/2010 | Hartwick Hawks 17 @ Ithaca 29 | † |
| 10/9/2010 | Ithaca 10 @ St John Fisher Cardinals 34 | † |
| 10/23/2010 | Springfield Pride 14 @ Ithaca 23 | † |
| 10/30/2010 | Utica Pioneers 6 @ Ithaca 30 | † |
| 11/6/2010 | Ithaca 17 @ Alfred Saxons 31 | † |
| 11/13/2010 | Ithaca 17 @ Cortland Red Dragons 20 |