| 9/4/2010 | St Lawrence 3 @ Ithaca Bombers 33 | |
| 9/11/2010 | Norwich Cadets 25 @ St Lawrence 14 | |
| 9/18/2010 | Alfred Saxons 24 @ St Lawrence 16 | |
| 9/25/2010 | St Lawrence 13 @ Merchant Marine Mariners 6 | † |
| 10/2/2010 | Hobart Statesmen 21 @ St Lawrence 24 | † |
| 10/9/2010 | St Lawrence 13 @ Utica Pioneers 31 | |
| 10/16/2010 | St Lawrence 23 @ Union NY Dutchmen 14 | † |
| 10/23/2010 | Rensselaer Engineers 3 @ St Lawrence 14 | † |
| 11/6/2010 | St Lawrence 7 @ Rochester Yellow Jackets 34 | † |
| 11/13/2010 | Worcester Polytechnic Engineers 7 @ St Lawrence 27 | † |
| 11/20/2010 | St Lawrence 0 @ Mount Union Purple Raiders 49 (D3 Playoffs Round 1) |