| 9/2/2010 | Johnson C Smith Golden Bulls 0 @ North Carolina Central 59 | |
| 9/11/2010 | Winston-Salem State Rams 34 @ North Carolina Central 27 | |
| 9/18/2010 | North Carolina Central 16 @ Appalachian State Mountaineers 44 | |
| 9/25/2010 | North Carolina A&T Aggies 16 @ North Carolina Central 27 | |
| 10/9/2010 | Hampton Pirates 27 @ North Carolina Central 13 | |
| 10/16/2010 | North Carolina Central 17 @ Georgia State Panthers 20 | |
| 10/23/2010 | Bethune-Cookman Wildcats 23 @ North Carolina Central 10 | |
| 10/30/2010 | Edward Waters Tigers 7 @ North Carolina Central 20 | |
| 11/6/2010 | North Carolina Central 7 @ Delaware State Hornets 29 | |
| 11/13/2010 | North Carolina Central 21 @ Savannah State Tigers 28 | † |
| 11/20/2010 | Old Dominion Monarchs 33 @ North Carolina Central 21 | † |