| 9/4/2010 | Edward Waters Tigers 10 @ Bethune-Cookman 70 | |
| 9/18/2010 | Savannah State Tigers 7 @ Bethune-Cookman 42 | |
| 9/25/2010 | Norfolk State Spartans 7 @ Bethune-Cookman 21 | † |
| 10/2/2010 | Bethune-Cookman 69 @ Morgan State Golden Bears 32 | † |
| 10/9/2010 | Delaware State Hornets 24 @ Bethune-Cookman 47 | † |
| 10/16/2010 | Bethune-Cookman 14 @ South Carolina State Bulldogs 0 | † |
| 10/23/2010 | Bethune-Cookman 23 @ North Carolina Central Eagles 10 | |
| 10/28/2010 | North Carolina A&T Aggies 17 @ Bethune-Cookman 67 | † |
| 11/6/2010 | Bethune-Cookman 23 @ Hampton Pirates 18 | † |
| 11/13/2010 | Howard Bison 20 @ Bethune-Cookman 35 | † |
| 11/20/2010 | Florida A&M Rattlers 38 vs Bethune-Cookman 27 (Orlando FL) | † |
| 12/4/2010 | New Hampshire Wildcats 45 @ Bethune-Cookman 20 |