| 9/4/2010 | Jacksonville 35 @ Old Dominion Monarchs 25 | |
| 9/11/2010 | Jacksonville 14 @ Appalachian State Mountaineers 45 | |
| 9/18/2010 | Webber International Warriors 0 @ Jacksonville 41 | |
| 9/25/2010 | Jacksonville 42 @ Davidson Wildcats 15 | † |
| 10/2/2010 | San Diego Toreros 28 @ Jacksonville 35 | † |
| 10/9/2010 | Drake Bulldogs 34 @ Jacksonville 39 | † |
| 10/16/2010 | Jacksonville 86 @ Valparaiso Crusaders 7 | † |
| 10/23/2010 | Marist Red Foxes 14 @ Jacksonville 56 | † |
| 10/30/2010 | Jacksonville 61 @ Morehead State Eagles 17 | † |
| 11/6/2010 | Jacksonville 24 @ Butler Bulldogs 16 | † |
| 11/13/2010 | Campbell Camels 24 @ Jacksonville 31 | † |