| 9/4/2010 | Sam Houston | @ | Baylor | ||||||
| 9/18/2010 | Sam Houston | @ | Western Illinois | ||||||
| 9/25/2010 | Gardner Webb | @ | Sam Houston | ||||||
| 10/2/2010 | Sam Houston | @ | Lamar | SLC | |||||
| 10/9/2010 | Sam Houston | @ | Nicholls St | SLC | |||||
| 10/16/2010 | SE Louisiana | @ | Sam Houston | SLC | |||||
| 10/23/2010 | SF Austin | vs | Sam Houston | SLC | |||||
| 10/30/2010 | Sam Houston | @ | Northwestern St | SLC | |||||
| 11/6/2010 | McNeese St | @ | Sam Houston | SLC | |||||
| 11/13/2010 | Sam Houston | @ | Central Arkansas | SLC | |||||
| 11/20/2010 | Texas St | @ | Sam Houston | SLC |