| 9/4/2010 | Nicholls St | @ | San Diego St | ||||||
| 9/11/2010 | Nicholls St | @ | Western Michigan | ||||||
| 9/18/2010 | Nicholls St | @ | South Alabama NAIA | ||||||
| 9/25/2010 | Bacone NAIA | @ | Nicholls St | ||||||
| 10/9/2010 | Sam Houston | @ | Nicholls St | SLC | |||||
| 10/16/2010 | Nicholls St | @ | Texas St | SLC | |||||
| 10/23/2010 | Central Arkansas | @ | Nicholls St | SLC | |||||
| 10/30/2010 | Nicholls St | @ | McNeese St | SLC | |||||
| 11/6/2010 | SF Austin | @ | Nicholls St | SLC | |||||
| 11/13/2010 | Nicholls St | @ | Northwestern St | SLC | |||||
| 11/18/2010 | SE Louisiana | @ | Nicholls St | SLC |