| 9/4/2010 | Lamar | @ | McNeese St | SLC | |||||
| 9/11/2010 | McNeese St | @ | Missouri | ||||||
| 9/25/2010 | Cal Poly | @ | McNeese St | ||||||
| 10/2/2010 | McNeese St | @ | Northwestern St | SLC | |||||
| 10/9/2010 | SF Austin | @ | McNeese St | SLC | |||||
| 10/16/2010 | McNeese St | @ | LSU | ||||||
| 10/23/2010 | McNeese St | @ | SE Louisiana | SLC | |||||
| 10/30/2010 | Nicholls St | @ | McNeese St | SLC | |||||
| 11/6/2010 | McNeese St | @ | Sam Houston | SLC | |||||
| 11/13/2010 | Texas St | @ | McNeese St | SLC | |||||
| 11/20/2010 | McNeese St | @ | Central Arkansas | SLC |