| 9/4/2010 | William & Mary | @ | Massachusetts | CAAF | |||||
| 9/11/2010 | Holy Cross | @ | Massachusetts | ||||||
| 9/18/2010 | Massachusetts | @ | Michigan | ||||||
| 9/25/2010 | Massachusetts | @ | Stony Brook | ||||||
| 10/2/2010 | Massachusetts | @ | Towson | CAAF | |||||
| 10/16/2010 | Richmond | @ | Massachusetts | CAAF | |||||
| 10/23/2010 | New Hampshire | vs | Massachusetts | CAAF | |||||
| 10/30/2010 | Massachusetts | @ | James Madison | CAAF | |||||
| 11/6/2010 | Maine | @ | Massachusetts | CAAF | |||||
| 11/13/2010 | Delaware | @ | Massachusetts | CAAF | |||||
| 11/20/2010 | Massachusetts | @ | Rhode Island | CAAF |