| 9/4/2010 | Howard | @ | Holy Cross | ||||||
| 9/11/2010 | Holy Cross | @ | Massachusetts | ||||||
| 9/18/2010 | Holy Cross | @ | Harvard | ||||||
| 9/25/2010 | Holy Cross | @ | Georgetown | Pat | |||||
| 10/2/2010 | Fordham | @ | Holy Cross | Pat | |||||
| 10/9/2010 | Brown | @ | Holy Cross | ||||||
| 10/16/2010 | Holy Cross | @ | Dartmouth | ||||||
| 10/23/2010 | Holy Cross | @ | Colgate | Pat | |||||
| 11/6/2010 | Lehigh | @ | Holy Cross | Pat | |||||
| 11/13/2010 | Holy Cross | @ | Lafayette | Pat | |||||
| 11/20/2010 | Bucknell | @ | Holy Cross | Pat |