| 9/2/2010 | Southern California | 49 | @ | Hawaii | 36 | ||||
| 9/11/2010 | Virginia | 7 | @ | Southern California | 17 | ||||
| 9/18/2010 | Southern California | 32 | @ | Minnesota | 21 | ||||
| 9/25/2010 | Southern California | 50 | @ | Washington State | 16 | P10 | |||
| 10/2/2010 | Washington | 32 | @ | Southern California | 31 | P10 | |||
| 10/9/2010 | Southern California | 35 | @ | Stanford | 37 | P10 | |||
| 10/16/2010 | California | 14 | @ | Southern California | 48 | P10 | |||
| 10/30/2010 | Oregon | 53 | @ | Southern California | 32 | P10 | |||
| 11/6/2010 | Arizona State | 33 | @ | Southern California | 34 | P10 | |||
| 11/13/2010 | Southern California | 24 | @ | Arizona | 21 | P10 | |||
| 11/20/2010 | Southern California | 7 | @ | Oregon State | 36 | P10 | |||
| 11/27/2010 | Notre Dame | 20 | @ | Southern California | 16 | ||||
| 12/4/2010 | Southern California | 28 | @ | UCLA | 14 | P10 |