| Thursday, 22 Nov 2007 | |||||||
| Tuskegee (D2) | 64 | @ | Alabama St | 58 | 2OT | ||
| P10 | Southern Cal | 44 | @ | Arizona St | 24 | ||
| Friday, 23 Nov 2007 | |||||||
| MAC | Central Michigan | 35 | @ | Akron | 32 | ||
| MAC | Toledo | 10 | @ | Bowling Green | 37 | ||
| B12 | Nebraska | 51 | @ | Colorado | 65 | ||
| MW | Wyoming | 28 | @ | Colorado St | 36 | ||
| Delaware St | 7 | @ | Delaware | 44 | |||
| WAC | Boise St | 27 | @ | Hawaii | 39 | ||
| SEC | Arkansas | 50 | @ | LSU | 48 | 3OT | |
| SEC | Mississippi | 14 | @ | Mississippi St | 17 | ||
| B12 | Texas | 30 | @ | Texas A&M | 38 | ||
| Saturday, 24 Nov 2007 | |||||||
| James Madison | 27 | @ | Appalachian St | 28 | |||
| SEC | Alabama | 10 | @ | Auburn | 17 | ||
| UW-Eau Claire (D3) | 12 | @ | Bethel MN (D3) | 21 | D3 Playoffs | ||
| St Francis IN (NAIA) | 30 | @ | Bethel TN (NAIA) | 27 | NAIA Quarterfinals | ||
| ACC | Miami FL | 14 | @ | Boston College | 28 | ||
| MW | Utah | 10 | @ | Brigham Young | 17 | ||
| Southern Conn St (D2) | 7 | @ | California PA (D2) | 43 | D2 Playoffs | ||
| Morningside (NAIA) | 16 | @ | Carroll MT (NAIA) | 27 | NAIA Quarterfinals | ||
| Wabash (D3) | 38 | @ | Case Western Reserve (D3) | 23 | D3 Playoffs | ||
| CUSA | UTEP | 20 | @ | Central Florida | 36 | ||
| St John's MN (D3) | 7 | @ | Central IA (D3) | 37 | D3 Playoffs | ||
| Abilene Christian (D2) | 73 | @ | Chadron St (D2) | 76 | 3OT | D2 Playoffs | |
| CUSA | Tulane | 12 | @ | East Carolina | 35 | ||
| Florida St | 12 | @ | Florida | 45 | |||
| SBC | Florida Atlantic | 55 | @ | Florida Int'l | 23 | ||
| Kansas St | 29 | @ | Fresno St | 45 | |||
| Georgia | 31 | @ | Georgia Tech | 17 | |||
| North Dakota (D2) | 14 | @ | Grand Valley St (D2) | 21 | D2 Playoffs | ||
| Texas Southern | 6 | @ | Houston | 59 | |||
| WAC | Utah St | 24 | @ | Idaho | 19 | ||
| MAC | Buffalo | 30 | @ | Kent St | 23 | OT | |
| SEC | Tennessee | 52 | @ | Kentucky | 50 | 4OT | Temmessee wins SEC East |
| SBC | Louisiana-Monroe | 17 | @ | Louisiana-Lafayette | 11 | ||
| CUSA | Alabama-Birmingham | 39 | @ | Marshall | 46 | ||
| North Carolina Wesleyan (D3) | 0 | @ | Mary Hardin-Baylor (D3) | 64 | D3 Playoffs | ||
| Fordham | 35 | @ | Massachusetts | 49 | |||
| Eastern Washington | 44 | @ | McNeese St | 15 | |||
| CUSA | SMU | 52 | @ | Memphis | 55 | 3OT | |
| B12 | Missouri | 36 | vs | Kansas | 28 | Kansas City MO | |
| Wofford | 23 | @ | Montana | 22 | |||
| New Jersey (D3) | 7 | @ | Mount Union (D3) | 59 | D3 Playoffs | ||
| NCC | Central Washington (D2) | 20 | @ | Nebraska-Omaha (D2) | 17 | D2 Playoffs | |
| MW | UNLV | 6 | @ | New Mexico | 27 | ||
| GSC | Delta St (D2) | 17 | @ | North Alabama (D2) | 20 | D2 Playoffs | |
| ACC | Duke | 14 | @ | North Carolina | 20 | OT | |
| ACC | Maryland | 37 | @ | North Carolina St | 0 | ||
| Western Kentucky | 26 | @ | North Texas | 27 | |||
| MAC | Ball St | 27 | @ | Northern Illinois | 21 | ||
| New Hampshire | 35 | @ | Northern Iowa | 38 | |||
| West Texas A&M (D2) | 28 | @ | NW Missouri St (D2) | 56 | D2 Playoffs | ||
| Missouri Valley (NAIA) | 48 | @ | Ohio Dominican (NAIA) | 34 | NAIA Quarterfinals | ||
| MAC | Miami OH | 29 | @ | Ohio U. | 38 | ||
| B12 | Oklahoma St | 17 | @ | Oklahoma | 49 | ||
| BigE | South Florida | 48 | @ | Pittsburgh | 37 | ||
| CUSA | Tulsa | 48 | @ | Rice | 43 | ||
| Eastern Kentucky | 14 | @ | Richmond | 31 | |||
| MW | TCU | 45 | @ | San Diego St | 33 | ||
| WAC | Nevada | 24 | @ | San Jose St | 27 | ||
| Indiana PA (D2) | 34 | @ | Shepherd (D2) | 41 | D2 Playoffs | ||
| St Xavier (NAIA) | 7 | @ | Sioux Falls (NAIA) | 49 | NAIA Quarterfinals | ||
| Clemson | 23 | @ | South Carolina | 21 | |||
| Eastern Illinois | 11 | @ | Southern Illinois | 30 | |||
| Arkansas St | 10 | @ | Southern Miss | 16 | |||
| SWAC | Southern U. | 22 | vs | Grambling St | 13 | New Orleans LA | |
| Curry (D3) | 7 | @ | St John Fisher (D3) | 38 | D3 Playoffs | ||
| Notre Dame | 21 | @ | Stanford | 14 | |||
| BigE | Cincinnati | 52 | @ | Syracuse | 31 | ||
| P10 | Oregon | 0 | @ | UCLA | 16 | ||
| North Central (D3) | 28 | @ | UW-Whitewater (D3) | 59 | D3 Playoffs | ||
| Catawba (D2) | 29 | @ | Valdosta St (D2) | 55 | D2 Playoffs | ||
| Wake Forest | 31 | @ | Vanderbilt | 17 | |||
| ACC | Virginia Tech | 33 | @ | Virginia | 21 | ||
| P10 | Washington St | 42 | @ | Washington | 35 | ||
| Muhlenberg (D3) | 21 | @ | Wesley (D3) | 38 | D3 Playoffs | ||
| BigE | Connecticut | 21 | @ | West Virginia | 66 | ||
| MAC | Temple | 3 | @ | Western Michigan | 16 | ||