| 8/30/2007 | Quincy NAIA | 14 | @ | Southern Illinois | 59 | ||||
| 9/8/2007 | Southern Illinois | 34 | @ | Northern Illinois | 31 | ||||
| 9/15/2007 | Southern Illinois | 44 | @ | S Utah | 10 | ||||
| 9/22/2007 | Ark Pine Bluff | 3 | @ | Southern Illinois | 58 | ||||
| 9/29/2007 | Southern Illinois | 72 | @ | Indiana St | 10 | GW | |||
| 10/6/2007 | Youngstown St | 17 | @ | Southern Illinois | 24 | GW | |||
| 10/13/2007 | Southern Illinois | 24 | @ | Northern Iowa | 30 | GW | |||
| 10/20/2007 | Missouri State | 10 | @ | Southern Illinois | 45 | GW | |||
| 11/3/2007 | Southern Illinois | 10 | @ | Western Illinois | 9 | GW | |||
| 11/10/2007 | Illinois St | 24 | @ | Southern Illinois | 34 | GW | |||
| 11/17/2007 | Southern Illinois | 45 | @ | Hampton | 27 | ||||
| 11/24/2007 | Eastern Illinois | 11 | @ | Southern Illinois | 30 | ||||
| 12/1/2007 | Massachusetts | 27 | @ | Southern Illinois | 34 | FCS Quarterfinals | |||
| 12/8/2007 | Delaware | 20 | @ | Southern Illinois | 17 | FCS Semifinal |