| 9/4/2005 | #11 Virginia Tech | 20 | @ | North Carolina St | 16 | ACC | |||
| 9/10/2005 | #11 Virginia Tech | 45 | @ | Duke | 0 | ACC | |||
| 9/17/2005 | Ohio | 0 | @ | #11 Virginia Tech | 45 | ||||
| 9/24/2005 | #24 Georgia Tech | 7 | @ | #11 Virginia Tech | 51 | ACC | |||
| 10/1/2005 | #11 Virginia Tech | 34 | @ | #11 West Virginia | 17 | ||||
| 10/8/2005 | Marshall | 14 | @ | #11 Virginia Tech | 41 | ||||
| 10/20/2005 | #11 Virginia Tech | 28 | @ | Maryland | 9 | ACC | |||
| 10/27/2005 | #19 Boston College | 10 | @ | #11 Virginia Tech | 30 | ACC | |||
| 11/5/2005 | #9 Miami-Florida | 27 | @ | #11 Virginia Tech | 7 | ACC | |||
| 11/19/2005 | #11 Virginia Tech | 52 | @ | Virginia | 14 | ACC | |||
| 11/26/2005 | North Carolina | 3 | @ | #11 Virginia Tech | 30 | ACC | |||
| 12/3/2005 | #11 Virginia Tech | 22 | vs | #22 Florida St | 27 | ACC | ACC CG | ||
| 1/2/2006 | #11 Virginia Tech | 35 | vs | #15 Louisville | 24 | Gator |