| 9/4/2005 | #11 Virginia Tech | 20 | @ | North Carolina St | 16 | ACC | |||
| 9/17/2005 | Eastern Kentucky | 10 | @ | North Carolina St | 54 | ||||
| 9/24/2005 | North Carolina | 31 | @ | North Carolina St | 24 | ACC | |||
| 10/6/2005 | North Carolina St | 17 | @ | #24 Georgia Tech | 14 | ACC | |||
| 10/13/2005 | #23 Clemson | 31 | @ | North Carolina St | 10 | ACC | |||
| 10/22/2005 | North Carolina St | 19 | @ | Wake Forest | 27 | ACC | |||
| 10/29/2005 | Southern Miss | 17 | @ | North Carolina St | 21 | ||||
| 11/5/2005 | North Carolina St | 20 | @ | #22 Florida St | 15 | ACC | |||
| 11/12/2005 | North Carolina St | 10 | @ | #19 Boston College | 30 | ACC | |||
| 11/19/2005 | Middle Tenn St | 3 | @ | North Carolina St | 24 | ||||
| 11/26/2005 | Maryland | 14 | @ | North Carolina St | 20 | ACC | |||
| 12/31/2005 | North Carolina St | 14 | vs | South Florida | 0 | Meineke |