| 9/4/2005 | #15 Louisville | 31 | @ | Kentucky | 24 | ||||
| 9/17/2005 | Oregon St | 27 | @ | #15 Louisville | 63 | ||||
| 9/24/2005 | #15 Louisville | 14 | @ | South Florida | 45 | BigE | |||
| 10/1/2005 | Florida Atlantic | 10 | @ | #15 Louisville | 16 | ||||
| 10/8/2005 | North Carolina | 14 | @ | #15 Louisville | 69 | ||||
| 10/15/2005 | #15 Louisville | 44 | @ | #11 West Virginia | 46 | 3 OT | BigE | ||
| 10/22/2005 | #15 Louisville | 46 | @ | Cincinnati | 22 | BigE | |||
| 11/3/2005 | Pittsburgh | 20 | @ | #15 Louisville | 42 | BigE | |||
| 11/11/2005 | Rutgers | 5 | @ | #15 Louisville | 56 | BigE | |||
| 11/26/2005 | Syracuse | 17 | @ | #15 Louisville | 41 | BigE | |||
| 12/3/2005 | #15 Louisville | 30 | @ | Connecticut | 20 | BigE | |||
| 1/2/2006 | #11 Virginia Tech | 35 | vs | #15 Louisville | 24 | Gator |