| 9/3/2005 | Texas A&M | 24 | @ | #23 Clemson | 25 | ||||
| 9/10/2005 | #23 Clemson | 28 | @ | Maryland | 24 | ACC | |||
| 9/17/2005 | #9 Miami-Florida | 36 | @ | #23 Clemson | 30 | ACC | |||
| 9/24/2005 | #19 Boston College | 16 | @ | #23 Clemson | 13 | OT | ACC | ||
| 10/1/2005 | #23 Clemson | 27 | @ | Wake Forest | 31 | ACC | |||
| 10/13/2005 | #23 Clemson | 31 | @ | North Carolina St | 10 | ACC | |||
| 10/22/2005 | Temple | 7 | @ | #23 Clemson | 37 | ||||
| 10/29/2005 | #23 Clemson | 9 | @ | #24 Georgia Tech | 10 | ACC | |||
| 11/5/2005 | Duke | 20 | @ | #23 Clemson | 49 | ACC | |||
| 11/12/2005 | #22 Florida St | 14 | @ | #23 Clemson | 35 | ACC | |||
| 11/19/2005 | #23 Clemson | 13 | @ | South Carolina | 9 | ||||
| 12/27/2005 | #23 Clemson | 19 | vs | Colorado | 10 | Champs Sports |