| 9/3/2005 | Middle Tenn St | 7 | @ | #13 Alabama | 26 | ||||
| 9/10/2005 | North Texas | 14 | @ | Middle Tenn St | 7 | SBC | |||
| 9/17/2005 | Akron | 14 | @ | Middle Tenn St | 7 | ||||
| 10/1/2005 | Middle Tenn St | 17 | @ | Vanderbilt | 15 | ||||
| 10/15/2005 | Middle Tenn St | 35 | @ | Florida Atlantic | 14 | SBC | |||
| 10/22/2005 | UL Lafayette | 13 | @ | Middle Tenn St | 10 | SBC | |||
| 10/29/2005 | Middle Tenn St | @ | Florida Intl | SBC | Ppd | ||||
| 11/5/2005 | Arkansas St | 7 | @ | Middle Tenn St | 45 | SBC | |||
| 11/12/2005 | UL Monroe | 34 | @ | Middle Tenn St | 31 | SBC | |||
| 11/19/2005 | Middle Tenn St | 3 | @ | North Carolina St | 24 | ||||
| 11/26/2005 | Middle Tenn St | 17 | @ | Troy | 7 | SBC | |||
| 12/3/2005 | Middle Tenn St | 31 | @ | Florida Intl | 35 | SBC |