| 9/3/2005 | Arkansas St | 17 | vs | Missouri | 44 | Kansas City MO | |||
| 9/10/2005 | New Mexico | 45 | @ | Missouri | 35 | ||||
| 9/17/2005 | Troy | 21 | @ | Missouri | 52 | ||||
| 10/1/2005 | #2 Texas | 51 | @ | Missouri | 20 | B12 | |||
| 10/8/2005 | Missouri | 38 | @ | Oklahoma St | 31 | B12 | |||
| 10/15/2005 | Iowa State | 24 | @ | Missouri | 27 | OT | B12 | ||
| 10/22/2005 | Nebraska | 24 | @ | Missouri | 41 | B12 | |||
| 10/29/2005 | Missouri | 3 | @ | Kansas | 13 | B12 | |||
| 11/5/2005 | Missouri | 12 | @ | Colorado | 41 | B12 | |||
| 11/12/2005 | Baylor | 16 | @ | Missouri | 31 | B12 | |||
| 11/19/2005 | Missouri | 28 | @ | Kansas St | 36 | B12 | |||
| 12/30/2005 | Missouri | 38 | vs | South Carolina | 31 | Independence |