| 9/3/2005 | Illinois St | 21 | @ | Iowa State | 32 | ||||
| 9/10/2005 | #25 Iowa | 3 | @ | Iowa State | 23 | ||||
| 9/23/2005 | Iowa State | 28 | @ | Army | 21 | ||||
| 10/1/2005 | Iowa State | 20 | @ | Nebraska | 27 | 2 OT | B12 | ||
| 10/8/2005 | Baylor | 23 | @ | Iowa State | 13 | B12 | |||
| 10/15/2005 | Iowa State | 24 | @ | Missouri | 27 | OT | B12 | ||
| 10/22/2005 | Oklahoma St | 10 | @ | Iowa State | 37 | B12 | |||
| 10/29/2005 | Iowa State | 42 | @ | Texas A&M | 14 | B12 | |||
| 11/5/2005 | Kansas St | 17 | @ | Iowa State | 45 | B12 | |||
| 11/12/2005 | Colorado | 16 | @ | Iowa State | 30 | B12 | |||
| 11/26/2005 | Iowa State | 21 | @ | Kansas | 24 | OT | B12 | ||
| 12/31/2005 | Iowa State | 24 | vs | #14 TCU | 27 | Houston |