| 9/1/2005 | Eastern Michigan | 26 | @ | Cincinnati | 28 | ||||
| 9/10/2005 | Cincinnati | 24 | @ | #3 Penn State | 42 | ||||
| 9/17/2005 | Western Carolina | 3 | @ | Cincinnati | 7 | ||||
| 9/28/2005 | Cincinnati | 16 | @ | Miami-Ohio | 44 | ||||
| 10/8/2005 | Cincinnati | 20 | @ | Pittsburgh | 38 | BigE | |||
| 10/15/2005 | Connecticut | 17 | @ | Cincinnati | 28 | BigE | |||
| 10/22/2005 | #15 Louisville | 46 | @ | Cincinnati | 22 | BigE | |||
| 10/29/2005 | Cincinnati | 22 | @ | Syracuse | 16 | BigE | |||
| 11/9/2005 | #11 West Virginia | 38 | @ | Cincinnati | 0 | BigE | |||
| 11/19/2005 | Cincinnati | 16 | @ | South Florida | 31 | BigE | |||
| 11/26/2005 | Cincinnati | 9 | @ | Rutgers | 44 | BigE |