| 8/28/2021 | Dakota State | 6 | at | Dakota Wesleyan (4-7) | 0 | at GPAC | ||
| 9/4/2021 | Wisconsin-La Crosse (9-3) | 42 | at | Dakota State | 21 | WIAC (D3) | ||
| 9/18/2021 | Presentation (0-11,0-7) | 13 | at | Dakota State | 40 | |||
| 9/25/2021 | Mayville State (2-9,1-6) | 16 | at | Dakota State | 20 | |||
| 10/2/2021 | Dakota State | 21 | at | Waldorf (7-3,4-3) | 26 | |||
| 10/9/2021 | Dakota State | 14 | at | Dickinson State (8-3,7-0) | 34 | |||
| 10/16/2021 | Valley City State (8-2,5-2) | 10 | at | Dakota State | 24 | |||
| 10/23/2021 | Iowa Wesleyan (2-9) | 15 | at | Dakota State | 53 | NAIAInd | ||
| 11/6/2021 | Dakota State | 7 | at | Valley City State (8-2,5-2) | 33 | |||
| 11/13/2021 | Dakota State | 16 | at | Presentation (0-11,0-7) | 14 |
| vs Dakota State | vs Other Opponents | Dakota State compared to OOs | |
| Record: | 4-6 | 43-51 | |
| Points Scored: | 20.30 | 25.77 | 5.47 |
| Points Allowed: | 22.20 | 30.34 | -8.14 |
| Margin: | -1.90 | -4.57 | -2.67 |
| Total Points: | 42.50 | 56.11 | -13.61 |