| 8/26/2021 | Jamestown (2-9) | 7 | at | Valley City State | 24 | GPAC | ||
| 9/4/2021 | Valley City State | 35 | at | Concordia-Moorhead (4-6) | 32 | at MIA | ||
| 9/18/2021 | Waldorf (7-3,4-3) | 7 | at | Valley City State | 14 | |||
| 9/25/2021 | Valley City State | 28 | at | Iowa Wesleyan (2-9) | 14 | at NAIAInd | ||
| 10/2/2021 | Mayville State (2-9,1-6) | 0 | at | Valley City State | 49 | |||
| 10/9/2021 | Valley City State | 44 | at | Presentation (0-11,0-7) | 10 | |||
| 10/16/2021 | Valley City State | 10 | at | Dakota State (6-4,4-3) | 24 | |||
| 10/23/2021 | Dickinson State (8-3,7-0) | 14 | at | Valley City State | 7 | |||
| 10/30/2021 | Valley City State | 21 | at | Waldorf (7-3,4-3) | 14 | |||
| 11/6/2021 | Dakota State (6-4,4-3) | 7 | at | Valley City State | 33 |
| vs Valley City State | vs Other Opponents | Valley City State compared to OOs | |
| Record: | 2-8 | 41-50 | |
| Points Scored: | 12.90 | 26.85 | 13.95 |
| Points Allowed: | 26.50 | 31.42 | -4.92 |
| Margin: | -13.60 | -4.57 | 9.03 |
| Total Points: | 39.40 | 58.27 | -18.87 |