| 9/4/2021 | Geneva (4-6) | 35 | at | Wooster | 42 | TPAC | ||
| 9/11/2021 | Kenyon (3-7,3-6) | 7 | at | Wooster | 49 | |||
| 9/18/2021 | Wooster | 7 | at | Ohio Wesleyan (8-2,7-2) | 31 | |||
| 9/25/2021 | DePauw (9-3,8-1) | 34 | at | Wooster | 30 | |||
| 10/2/2021 | Wooster | 28 | at | Oberlin (1-9,1-8) | 24 | |||
| 10/16/2021 | Wooster | 44 | at | Wabash (7-3,6-3) | 41 | |||
| 10/23/2021 | Wooster | 28 | at | Denison (6-4,6-3) | 52 | |||
| 10/30/2021 | Hiram (1-9,0-9) | 14 | at | Wooster | 51 | |||
| 11/6/2021 | Allegheny (3-7,2-7) | 41 | at | Wooster | 59 | |||
| 11/13/2021 | Wooster | 29 | at | Wittenberg (7-3,7-2) | 44 |
| vs Wooster | vs Other Opponents | Wooster compared to OOs | |
| Record: | 4-6 | 45-47 | |
| Points Scored: | 32.30 | 28.05 | -4.25 |
| Points Allowed: | 36.70 | 28.13 | 8.57 |
| Margin: | -4.40 | -0.08 | 4.32 |
| Total Points: | 69.00 | 56.18 | 12.82 |