| 9/4/2021 | Wabash | 33 | at | Rose-Hulman (8-3) | 23 | at HCA | ||
| 9/11/2021 | Wabash | 42 | at | Hiram (1-9,0-9) | 14 | |||
| 9/18/2021 | Allegheny (3-7,2-7) | 28 | at | Wabash | 36 | |||
| 10/2/2021 | Wabash | 39 | at | Denison (6-4,6-3) | 38 | OT | ||
| 10/9/2021 | Oberlin (1-9,1-8) | 20 | at | Wabash | 49 | |||
| 10/16/2021 | Wooster (6-4,5-4) | 44 | at | Wabash | 41 | |||
| 10/23/2021 | Wabash | 28 | at | Ohio Wesleyan (8-2,7-2) | 35 | OT | ||
| 10/30/2021 | Wabash | 59 | at | Kenyon (3-7,3-6) | 34 | |||
| 11/6/2021 | Wittenberg (7-3,7-2) | 35 | at | Wabash | 14 | |||
| 11/13/2021 | DePauw (9-3,8-1) | 35 | at | Wabash | 42 |
| vs Wabash | vs Other Opponents | Wabash compared to OOs | |
| Record: | 3-7 | 49-44 | |
| Points Scored: | 30.60 | 29.34 | -1.26 |
| Points Allowed: | 38.30 | 27.40 | 10.90 |
| Margin: | -7.70 | 1.94 | 9.64 |
| Total Points: | 68.90 | 56.74 | 12.16 |