| 9/4/2021 | Denison | 10 | at | Ohio Northern (4-6) | 34 | at OAC | ||
| 9/11/2021 | Allegheny (3-7,2-7) | 0 | at | Denison | 31 | |||
| 9/18/2021 | Denison | 59 | at | Oberlin (1-9,1-8) | 12 | |||
| 9/25/2021 | Wittenberg (7-3,7-2) | 16 | at | Denison | 21 | |||
| 10/2/2021 | Wabash (7-3,6-3) | 39 | at | Denison | 38 | OT | ||
| 10/16/2021 | Denison | 45 | at | Kenyon (3-7,3-6) | 7 | |||
| 10/23/2021 | Wooster (6-4,5-4) | 28 | at | Denison | 52 | |||
| 10/30/2021 | Denison | 10 | at | DePauw (9-3,8-1) | 27 | |||
| 11/6/2021 | Denison | 59 | at | Hiram (1-9,0-9) | 6 | |||
| 11/13/2021 | Ohio Wesleyan (8-2,7-2) | 35 | at | Denison | 25 |
| vs Denison | vs Other Opponents | Denison compared to OOs | |
| Record: | 4-6 | 45-47 | |
| Points Scored: | 20.40 | 29.95 | 9.55 |
| Points Allowed: | 35.00 | 29.65 | 5.35 |
| Margin: | -14.60 | 0.30 | 14.90 |
| Total Points: | 55.40 | 59.60 | -4.20 |