| 9/4/2021 | Plymouth State | 0 | at | Castleton State (6-4) | 13 | at ECFC | ||
| 9/11/2021 | Husson (7-3) | 10 | at | Plymouth State | 7 | CCF | ||
| 9/18/2021 | Plymouth State | 24 | at | Bridgewater State MA (6-4,6-2) | 27 | |||
| 10/2/2021 | Framingham State (8-3,8-0) | 33 | at | Plymouth State | 0 | |||
| 10/9/2021 | Plymouth State | 16 | at | Western Connecticut (5-5,4-4) | 13 | |||
| 10/16/2021 | Fitchburg State (0-10,0-8) | 0 | at | Plymouth State | 36 | |||
| 10/23/2021 | Worcester State (3-7,3-5) | 14 | at | Plymouth State | 42 | |||
| 10/30/2021 | Plymouth State | 17 | at | Westfield State (1-9,1-7) | 7 | |||
| 11/6/2021 | Massachusetts Maritime (4-6,3-5) | 7 | at | Plymouth State | 27 | |||
| 11/13/2021 | Plymouth State | 7 | at | UMass Dartmouth (9-2,6-2) | 28 |
| vs Plymouth State | vs Other Opponents | Plymouth State compared to OOs | |
| Record: | 5-5 | 44-48 | |
| Points Scored: | 15.20 | 23.15 | 7.95 |
| Points Allowed: | 17.60 | 25.77 | -8.17 |
| Margin: | -2.40 | -2.62 | -0.22 |
| Total Points: | 32.80 | 48.92 | -16.12 |