| 9/4/2021 | Brockport State (8-3) | 31 | at | Framingham State | 0 | E8 | ||
| 9/11/2021 | Framingham State | 7 | at | St John Fisher (4-6) | 38 | at E8 | ||
| 9/18/2021 | UMass Dartmouth (9-2,6-2) | 21 | at | Framingham State | 45 | |||
| 9/25/2021 | Westfield State (1-9,1-7) | 6 | at | Framingham State | 41 | |||
| 10/2/2021 | Framingham State | 33 | at | Plymouth State (5-5,5-3) | 0 | |||
| 10/9/2021 | Framingham State | 35 | at | Fitchburg State (0-10,0-8) | 0 | |||
| 10/16/2021 | Western Connecticut (5-5,4-4) | 21 | at | Framingham State | 35 | |||
| 10/30/2021 | Framingham State | 23 | at | Massachusetts Maritime (4-6,3-5) | 14 | |||
| 11/6/2021 | Bridgewater State MA (6-4,6-2) | 13 | at | Framingham State | 47 | |||
| 11/13/2021 | Framingham State | 40 | at | Worcester State (3-7,3-5) | 21 | |||
| 11/20/2021 | Framingham State | 0 | at | Muhlenberg (11-2) | 45 | at Cen |
| vs Framingham State | vs Other Opponents | Framingham State compared to OOs | |
| Record: | 3-8 | 53-51 | |
| Points Scored: | 19.09 | 23.55 | 4.46 |
| Points Allowed: | 27.82 | 23.04 | 4.78 |
| Margin: | -8.73 | 0.51 | 9.24 |
| Total Points: | 46.91 | 46.59 | 0.32 |