| 9/4/2021 | UMass Dartmouth (9-2) | 21 | at | Husson | 14 | MSCAC | ||
| 9/11/2021 | Husson | 10 | at | Plymouth State (5-5) | 7 | at MSCAC | ||
| 9/17/2021 | Dean (2-8) | 14 | at | Husson | 42 | ECFC | ||
| 9/25/2021 | Springfield (7-4) | 21 | at | Husson | 26 | NEWMAC | ||
| 10/9/2021 | Curry (3-6,1-5) | 14 | at | Husson | 21 | |||
| 10/16/2021 | Endicott (8-3,5-1) | 24 | at | Husson | 17 | |||
| 10/23/2021 | Husson | 41 | at | University of New England (4-5,2-4) | 14 | |||
| 10/30/2021 | Husson | 14 | at | Nichols (2-8,0-6) | 12 | |||
| 11/6/2021 | Salve Regina (8-2,4-2) | 10 | at | Husson | 24 | |||
| 11/13/2021 | Husson | 10 | at | Western New England (7-4,5-1) | 35 |
| vs Husson | vs Other Opponents | Husson compared to OOs | |
| Record: | 3-7 | 52-40 | |
| Points Scored: | 17.20 | 25.85 | 8.65 |
| Points Allowed: | 21.90 | 22.80 | -0.90 |
| Margin: | -4.70 | 3.05 | 7.75 |
| Total Points: | 39.10 | 48.65 | -9.55 |