| 9/2/2021 | Lakeland (8-2) | 28 | at | Illinois College | 18 | NAC | ||
| 9/11/2021 | Illinois College | 14 | at | Chicago (8-2,7-2) | 66 | |||
| 9/18/2021 | Monmouth IL (8-2,8-1) | 37 | at | Illinois College | 27 | |||
| 10/2/2021 | Illinois College | 13 | at | Ripon (6-3,5-3) | 24 | |||
| 10/9/2021 | Lake Forest (10-1,9-0) | 48 | at | Illinois College | 13 | |||
| 10/16/2021 | Illinois College | 38 | at | Lawrence (2-7,1-7) | 37 | |||
| 10/23/2021 | Knox (3-6,3-6) | 20 | at | Illinois College | 27 | |||
| 10/30/2021 | Illinois College | 39 | at | Cornell IA (4-6,4-5) | 7 | |||
| 11/6/2021 | Grinnell (2-8,2-7) | 24 | at | Illinois College | 55 | |||
| 11/13/2021 | Illinois College | 21 | at | Beloit (0-10,0-9) | 3 |
| vs Illinois College | vs Other Opponents | Illinois College compared to OOs | |
| Record: | 5-5 | 46-42 | |
| Points Scored: | 29.40 | 29.80 | 0.40 |
| Points Allowed: | 26.50 | 28.59 | -2.09 |
| Margin: | 2.90 | 1.21 | -1.69 |
| Total Points: | 55.90 | 58.39 | -2.49 |